Bienvenu(e) sur le site de l'Institut Necker Enfants Malades
Séminaires
Vendredi 2 février 2024 à 12:00
Mitochondrial mechanotransduction coordinates the nuclear response to forces
Sirio Dupont
University of Padua
Invité par Fabiola Terzi
INEM - Auditorium 1

Sirio Dupont is a unique individual in a family of artists and humanists. He made the unconventional choice to pursue a career in science, earning a Molecular Biology Master's Degree at the University of Padua. His passion for developmental biology led him to pursue a Ph.D., which he successfully completed in 2004, also at the University of Padua.

With outstanding results and an unyielding passion for his field, Professor Dupont entered the world of academia and became an Assistant Professor in 2006, still at the University of Padua. Throughout this journey, his family continued to grow, and he explored new research avenues. Notably, he achieved a 'once in a lifetime' discovery.

In 2013, Professor Dupont took the next step in his career by establishing an independent research group, once again, in Padua. Over the past decade, he has led this research group with enthusiasm, finding immense joy in scientific exploration. Alongside these professional accomplishments, his family continued to thrive, all with the constant presence of his supportive wife.

In recognition of his exceptional contributions to science and his unwavering dedication, Professor Dupont was appointed as a Full Professor in 2023, at the University of Padua.

Vendredi 9 février 2024 à 12:00
New strategies for the diagnostic and treatment of allergic diseases
Laurent Reber
Institut Toulousain des Maladies Infectieuses et Inflammatoires 
Invité par Simon Fillatreau
INEM - Auditorium 1

Laurent Reber completed a Ph.D. at the University of Strasbourg in 2009, conducting research in the laboratory of Nelly Frossard. Following the completion of the Ph.D., they embarked on a postdoctoral fellowship in the laboratory of Steve Galli at Stanford University, where they focused on the biology of mast cells and their pivotal role in allergic diseases.

In 2016, Dr Reber was recruited by INSERM and joined the team led by Pierre Bruhns at Institut Pasteur in Paris. There, they continued their research endeavors, delving deeper into the mechanisms underlying allergic diseases and anaphylaxis.

In 2019, Dr Reber established the ATIP-Avenir team "Asthma, Allergy & Immunotherapy" at the INFINITy Institute in Toulouse, solidifying their commitment to advancing our understanding of these conditions. Notably, in 2022, they achieved the prestigious honor of receiving an ERC Consolidator Grant for their pioneering work in developing long-term therapeutic strategies to address IgE-mediated allergic diseases.

Vendredi 16 février 2024 à 12:00
Unexpected roles of phosphoinositdes in aging and cancer
Emilio Hirsch
University of Torino
Invité par Ganna Panasyuk
INEM - Auditorium 1

Emilio Hirsch is Professor of Experimental Biology at the Medical School of the University of Torino, Italy since 2005. He authored 301 publications, has an h-index of 90 (google Scholar), is EMBO member, FISHR, Scientific Director of the Molinette Research Foundation and Director of the Molecular Biotechnology Center.

Professor Hirsch is co-founder of Kither Biotech, a preclinical stage biopharmaceutical company developing novel therapies for rare pulmonary diseases with high unmet medical needs like Cystic Fibrosis and Idiopathic Pulmonary Fibrosis. He provided seminal contributions in the characterization of phosphoinositide 3-kinases (PI3K) as drug targets in cancer and inflammation.

Lately, he focused his studies on the role of class 2 PI3K and found that the gene PIK3C2A is essential for cytokinesis. Children with loss of function mutations show cell refusion leading to cellular senescence and premature aging (Gulluni et al., Science 2021).

Vendredi 23 février 2024 à 12:00
Immunity and Tolerance in Persistent Viral Infection
Daniel Pinschewer
University of Basel
Invité par Jean-Claude Weill
INEM - Auditorium 1
Since 2013, Daniel Pinschewer serves as a full professor of Virology at the University of Basel, Switzerland. After graduating from the University of Zurich medical school in the year 2000 he trained as postdoctoral fellow in molecular virology at The Scripps Research Center, and in immunology at the University of Zurich. Prior to his current appointment he was an associate professor of immunology at the University of Geneva (2007-2013).
In recent years, his academic research and contributions to science have focused on the study of B cell responses to and their subversion by chronic viral infection, on the reverse engineering of arenaviruses for vectorized vaccine delivery and on the role of alarmins in protective antiviral T cell responses.
He is the recipient of career awards from the European Research Council and from the Swiss National Science Foundation. Patented discoveries made in my laboratory represent the technological basis of the vaccine and immunotherapy company HOOKIPA Pharma Inc. (Nasdaq HOOK), which he has co-founded. National and international honors received include the Georges-Köhler-Prize of the German Society for Immunology and the Loeffler-Frosch-Prize of the Society for Virology, the Debiopharm Group Life Sciences Award, the Pfizer Research Prize and the Prix Leenaards.
Vendredi 1er mars 2024 à 12:00
Role of adipose tissue myeloid cells in obesity and obesity-related disorders
Svetoslav Chakarov
Shanghai Jiao Tong University School of Medicine
Invité par Camille Blériot
INEM - Auditorium 1
Dr. Svetoslav Chakarov received his doctorate in immunology from Paul Sabatier University of Toulouse, France under the guidance of Professor Nicolas Fazilleau. He then joined Florent Ginhoux’s research team in Singapore Immunology Network as postdoctoral fellow. After concluding his postdoctoral training in 2020 he joined Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine as principal investigator and is currently head of “Myeloid cell biology and metabolism” laboratory.

Dr Chakarov group focus his research on adipose tissue myeloid cell diversity and their role in adipose tissue metabolic homeostasis. Recent work has been published in journals, such as Science, PNAS, Journal of Experimental Medicine. Dr. Chakarov is supported by National Natural Science Foundation of China (NSFC) and was selected into talent programs such as the NSFC National for Excellent Young Scientists Fund Program, Shanghai High-level Overseas Talent Introduction Program, Shanghai Foreign Experts Program.
 
Vendredi 8 mars 2024 à 12:00
Microbiota in the gut-liver-brain axis
Maria Rescigno
Humanitas University
Invité par Laurence Arbibe
INEM - Auditorium 1
Maria Rescigno is full professor, vice-rector and delegate to research at Humanitas University and group leader at Humanitas Research hospital, Milan. She graduated in Biology in the University of Milan and received her PhD in Pharmacology and toxicology. She served as a group leader at the European Institute of Oncology, a professor at the University of Milan, and a visiting professor at the University of Oslo. She was post-doctoral researcher at the University of Cambridge, UK, and earned her PhD from the CNR in Milan. She was elected an EMBO Young Investigator in 2007, became an EMBO member in 2011, and joined the EMBO Council in 2019, EMBO chair from 2023 onwards. She has received three ERC grants and has authored 221 publications. She has also received several awards, including an honorable mention (2022), the Roma Prize (2022), the Fondazione De Sanctis for Social Health Award (2023), and The Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award (2023). In 2016, she founded the startup Postbiotica, a spin-off of the University of Milan that exploits microbiota-derived metabolites as new pharmaceutical agents.
Vendredi 15 mars 2024 à 12:00
Targeting netrin-1 in cancer: from an alternative cell death mechanism to clinical development
Patrick Mehlen
Cancer Research Center of Lyon
Invité par Mario Pende
INEM - Auditorium 1
Patrick Mehlen is Director of Research at CNRS and director of the Cancer Research Center of Lyon. He is the leader of the dependence receptor paradigm and has deciphered the role of these receptors in pathological contexts. More specifically he has developed an anti-cancer candidate drug inhibiting the interaction of the ligand netrin-1 with its dependence receptors, that is currently assessed in several phase 2 clinical trials  He has published over 200 publications and received numerous awards such as the silver medal of CNRS, the Grand Prix Bettencourt des Sciences du Vivant, or the FSER price. He is elected member of EMBO since 2006 and of the National Academy of Sciences, Institut de France since 2013.
Adresse

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Parrain(s)
S.A.R. la Princesse Caroline de Hanovre qui, à travers la Fondation Princesse Grace, soutient déjà la recherche medicale et tout ce qui contribue à soulager les enfants malades en France et dans le monde, a accepté de s'engager à nos cotés pour que ce centre de medecine moleculaire, tourné entre autres vers les pathologies des enfants, prenne de vitesse les maladies et continue à relever les defis actuels.

INEM - Organigramme