Last 30 publications
2022
Foray AP, Candon S, Hildebrand S, Marquet C, Valette F, Pecquet C, Lemoine S, Langa-Vives F, Dumas M, Hu P, Santamaria P, You S, Lyon S, Scott L, Hui Bu C, Wang T, Xu D, Moresco EMY, Scazzocchio C, Bach JF, Beutler B, Chatenoud L.
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
Proc Natl Acad Sci U S A. 2021;118(47):e2112032118.
Azzout M, Dietrich C, Machavoine F, Gastineau P, Bottier A, Lezmi G, Leite-de-Moraes M.
IL-33 Enhances IFNγ and TNFα Production by Human MAIT Cells: A New Pro-Th1 Effect of IL-33
Int J Mol Sci. 2021;22(19):10602-12. doi: 10.3390/ijms221910602.
Lezmi G, Lejeune S, Pin I, Blanchon S, Bouazza N, Jolaine V, Marguet C, Houdoin V, Berger P, Fayon M, Dubus JC, Reix P, Pellan M, Brouard J, Chiron R, Giovannini-Chami L, Deschildre A, de Blic J, Group COS.
Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort.
J Allergy Clin Immunol Pract. 2021;9(5):1969-79. Epub 2020/12/29. doi: 10.1016/j.jaip.2020.12.027.
2021
Adel-Patient K, Grauso M, Abou-Taam R, Guillon B, Dietrich C, Machavoine F, Briard ,Garcelon N, Faour H, Neuraz A, Delacourt C, Molina TJ, Leite-de-Moraes M, Lezmi G.
A Comprehensive Analysis of Immune Constituents in Blood and Bronchoalveolar Lavage Allows Identification of an Immune Signature of Severe Asthma in Children.
Front Immunol. 2021;12:700521. Epub 2021/08/06. doi: 10.3389/fimmu.2021.700521
Bach JF, Berche P, Chatenoud L, Costagliola D, Valleron AJ.
COVID-19: individual and herd immunity.
C R Biol. 2021;344(1):7-18. Epub 2021/07/03. doi: 10.5802/crbiol.41.
Chavarot N, Ouedrani A, Marion O, Leruez-Ville M, Vilain E, Baaziz M, Del Bello A, Burger C, Sberro-Soussan R, Martinez F, Chatenoud L, Abravanel F, Anglicheau D, Izopet J, Couat C, Zuber J, Legendre C, Lanternier F, Kamar N, Scemla A.
Poor Anti-SARS-CoV-2 Humoral and T-cell Responses After 2 Injections of mRNA Vaccine in Kidney Transplant Recipients Treated With Belatacept.
Transplantation. 2021;105(9):e94-e5. Epub 2021/04/09. doi: 10.1097/TP.0000000000003784
Adel-Patient K, Grauso M, Abou-Taam R, Guillon B, Dietrich C, Machavoine F, Garcelon N, Briard M, Faour H, Neuraz A, Delacourt C, Molina TJ, Leite-de-Moraes M, Lezmi G.
Immune signatures distinguish frequent from non-frequent exacerbators among children with severe asthma.
Allergy. 2021. Epub 2021/02/06. doi: 10.1111/all.14759. PubMed PMID: 33544926.
2020
Baranek T, Lebrigand K, de Amat Herbozo C, Gonzalez L, Bogard G, Dietrich C, Magnone V, Boisseau C, Jouan Y, Trottein F, Si-Tahar M, Leite-de-Moraes M, Mallevaey T, Paget C. High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision. Cell Rep. 2020;32(10):108116. Epub 2020/09/10. doi: 10.1016/j.celrep.2020.108116. PubMed PMID: 32905761.
Candon S, Rammaert B, Foray AP, Moreira B, Gallego Hernanz MP, Chatenoud L, Lortholary O. Chronic Disseminated Candidiasis During Hematological Malignancies: An Immune Reconstitution Inflammatory Syndrome With Expansion of Pathogen-Specific T Helper Type 1 Cells. J Infect Dis. 2020;221(11):1907-16. Epub 2019/12/28. doi: 10.1093/infdis/jiz688. PubMed PMID: 31879764.
Fertitta L, Welfringer-Morin A, Ouedrani A, Polivka L, Chhun S, Chatenoud L, Fourgeaud J, Hadj-Rabia S, Temmam S, Eloit M, Sermet-Gaudelus I, Bodemer C. Immunological and virological profile of children with chilblain-like lesions and SARS-CoV-2. J Eur Acad Dermatol Venereol. 2020. Epub 2020/10/04. doi: 10.1111/jdv.16972. PubMed PMID: 33010072; PubMed Central PMCID: PMCPMC7675551.
Foray AP, Dietrich C, Pecquet C, Machavoine F, Chatenoud L, Leite-de-Moraes M. IL-4 and IL-17 are required for house dust mite-driven airway hyperresponsiveness in autoimmune diabetes-prone non obese diabetic mice. Front Immunol. 2020; in press. doi: 10.3389/fimmu.2020.595003
Hueso T, Pouderoux C, Pere H, Beaumont AL, Raillon LA, Ader F, Chatenoud L, Eshagh D, Szwebel TA, Martinot M, Camou F, Crickx E, Michel M, Mahevas M, Boutboul D, Azoulay E, Joseph A, Hermine O, Rouzaud C, Faguer S, Petua P, Pommeret F, Clerc S, Planquette B, Merabet F, London J, Zeller V, Ghez D, Veyer D, Ouedrani A, Gallian P, Pacanowski J, Mekinian A, Garnier M, Pirenne F, Tiberghien P, Lacombe K. Convalescent plasma therapy for B-cell-depleted patients with protracted COVID-19. Blood. 2020;136(20):2290-5. Epub 2020/09/23. doi: 10.1182/blood.2020008423. PubMed PMID: 32959052; PubMed Central PMCID: PMCPMC7702482.
Isnard P, Bruneau J, Sberro-Soussan R, Wendum D, Legendre C, Molina T, Chatenoud L, Hermine O, Rossignol J. Dissociation of humoral and cellular immune responses in kidney transplant recipients with EBV mucocutaneous ulcer. Transpl Infect Dis. 2020:e13552. Epub 2020/12/23. doi: 10.1111/tid.13552. PubMed PMID: 33352001.
Leite-de-Moraes M, Belo R, Dietrich C, Soussan D, Aubier M, Pretolani M. Circulating IL-4, IFNgamma and IL-17 conventional and Innate-like T-cell producers in adult asthma. Allergy. 2020. Epub 2020/07/01. doi: 10.1111/all.14474. PubMed PMID: 32603483.
Lepelley A, Martin-Niclos MJ, Le Bihan M, Marsh JA, Uggenti C, Rice GI, Bondet V, Duffy D, Hertzog J, Rehwinkel J, Amselem S, Boulisfane-El Khalifi S, Brennan M, Carter E, Chatenoud L, Chhun S, Coulomb l'Hermine A, Depp M, Legendre M, Mackenzie KJ, Marey J, McDougall C, McKenzie KJ, Molina TJ, Neven B, Seabra L, Thumerelle C, Wislez M, Nathan N, Manel N, Crow YJ, Fremond ML. Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling. J Exp Med. 2020;217(11). Epub 2020/07/30. doi: 10.1084/jem.20200600. PubMed PMID: 32725128.
Lozza L, Moura-Alves P, Domaszewska T, Crespo CL, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Ungureanu BS, Guhlich-Bornhof U, Koehler AB, Staber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J, 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. Author Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Sci Rep. 2020;10(1):8640. Epub 2020/05/21. doi: 10.1038/s41598-020-65510-2. PubMed PMID: 32433586; PubMed Central PMCID: PMCPMC7237648.
Martin E, Minet N, Boschat AC, Sanquer S, Sobrino S, Lenoir C, de Villartay JP, Leite-de-Moraes M, Picard C, Soudais C, Bourne T, Hambleton S, Hughes SM, Wynn RF, Briggs TA, Genomics England Research C, Patel S, Lawrence MG, Fischer A, Arkwright PD, Latour S. Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation. JCI Insight. 2020;5(5). Epub 2020/03/13. doi: 10.1172/jci.insight.133880. PubMed PMID: 32161190; PubMed Central PMCID: PMCPMC7141395.
Victor JR, Lezmi G, Leite-de-Moraes M. New Insights into Asthma Inflammation: Focus on iNKT, MAIT, and gammadelta T Cells. Clin Rev Allergy Immunol. 2020;59(3):371-81. Epub 2020/04/05. doi: 10.1007/s12016-020-08784-8. PubMed PMID: 32246390.
2019
Allali S, Dietrich C, Machavoine F, Rignault-Bricard R, Brousse V, de Montalembert M, Hermine O, Maciel TT, Leite-de-Moraes M. Innate-like T cells in children with sickle cell disease. PLoS One. 2019 14(6):e0219047. doi:10.1371/journal.pone.0219047
Belkadi A, Dietrich C, Machavoine F, Victor JR, Leite-de-Moraes M. gammadelta T cells amplify Blomia tropicalis-induced allergic airway disease. Allergy. 2019 Feb; 74(2):395-398. doi:10.1111/all.13618
Briand C, Fremond ML, Bessis D, Carbasse A, Rice GI, Bondet V, Duffy D, Chatenoud L, Blanche S, Crow YJ, Neven B. Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency. Ann Rheum Dis. 2019 Mar; 78(3):431-433. doi:10.1136/annrheumdis-2018-214037
Chatenoud L, Bertuccio P, Turati F, Galeone C, Naldi L, Chatenoud L, La Vecchia C, Bach JF, Group HS. Markers of microbial exposure lower the incidence of atopic dermatitis. Allergy. 2019 Jul 18; doi:10.1111/all.13990
Chatenoud L. A future for CD3 antibodies in immunotherapy of type 1 diabetes. Diabetologia. 2019 Apr; 62(4):578-581. doi:10.1007/s00125-018-4808-7
Courbette O, Aupiais C, Viala J, Hugot JP, Louveau B, Chatenoud L, Bourrat E, Martinez-Vinson C. Infliximab Paradoxical Psoriasis in a Cohort of Children With Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2019 Aug; 69(2):189-193. doi:10.1097/MPG.0000000000002349
de-Oliveira MG, Lira AAL, Sgnotto FR, Inoue AHS, Santos LS, Nakamatsu BY, Duarte AJS, Leite-de-Moraes M, Victor JR. Maternal IgG impairs the maturation of offspring intrathymic IL-17-producing gammadeltaT cells: Implications for murine and human allergies. Clin Exp Allergy. 2019 Jul; 49(7):1000-1012. doi:10.1111/cea.13393
Duchatelet S, Join-Lambert O, Delage M, Miskinyte S, Guet-Revillet H, Lam T, Coignard-Biehler H, Ungeheuer MN, Chatenoud L, Lortholary O, Nassif X, Hovnanian A, Nassif AS. Remission of chronic acne fulminans and severe hidradenitis suppurativa with targeted antibiotherapy. JAAD Case Rep. 2019 Jun; 5(6):525-528. doi:10.1016/j.jdcr.2019.04.001
Lezmi G, Abou-Taam R, Garcelon N, Dietrich C, Machavoine F, Delacourt C, Adel-Patient K, Leite-de-Moraes M. Evidence for a MAIT-17-high phenotype in children with severe asthma. J Allergy Clin Immunol. 2019 Aug 16; doi:10.1016/j.jaci.2019.08.003c
Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Staber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J, 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE. The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Sci Rep. 2019 Jul 26; 9(1):10878. doi:10.1038/s41598-019-47350-x
Neven B, Diana JS, Castelle M, Magnani A, Rosain J, Touzot F, Moreira B, Fremond ML, Briand C, Bendavid M, Levy R, Morelle G, Vincent M, Magrin E, Bourget P, Chatenoud L, Picard C, Fischer A, Moshous D, Blanche S. Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide for Primary Immunodeficiencies and Inherited Disorders in Children. Biol Blood Marrow Transplant. 2019 Jul; 25(7):1363-1373. doi:10.1016/j.bbmt.2019.03.009
2018
Bach JF. The hygiene hypothesis in autoimmunity: the role of pathogens and commensals. Nat Rev Immunol. 2018;18(2):105-20. doi: 10.1038/nri.2017.111. PubMed PMID: 29034905.
Besancon A, Demir Z, Goncalves T, Valette F, Panafieu E, Chatenoud L, You S. Differential Impact of T-bet and IFNgamma on Pancreatic Islet Allograft Rejection. Transplantation. 2018 Sep; 102(9):1496-1504. doi:10.1097/TP.0000000000002261
Besancon A, Goncalves T, Valette F, Mary C, Vanhove B, Chatenoud L, You S. A selective CD28 antagonist and rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice. Diabetologia. 2018;61(8):1811-6. doi: 10.1007/s00125-018-4638-7. PubMed PMID: 29845333
Besancon A, Goncalves T, Valette F, Dahllof MS, Mandrup-Poulsen T, Chatenoud L, You S. Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice. Diabetologia. 2018;61(2):389-98. doi: 10.1007/s00125-017-4459-0. PubMed PMID: 29030662
Briand C, Fremond ML, Bessis D, Carbasse A, Rice GI, Bondet V, Duffy D, Chatenoud L, Blanche S, Crow YJ, Neven B. Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency. Ann Rheum Dis. 2018. doi: 10.1136/annrheumdis-2018-214037. PubMed PMID: 30282666
Delliere S, Guery R, Candon S, Rammaert B, Aguilar C, Lanternier F, Chatenoud L, Lortholary O. Understanding Pathogenesis and Care Challenges of Immune Reconstitution Inflammatory Syndrome in Fungal Infections. J Fungi (Basel). 2018 Dec 17; 4(4):doi:10.3390/jof4040139
Ghiasi SM, Dahllof MS, Osmai Y, Osmai M, Jakobsen KK, Aivazidis A, Tyrberg B, Perruzza L, Prause MCB, Christensen DP, Fog-Tonnesen M, Lundh M, Grassi F, Chatenoud L, Mandrup-Poulsen T. Regulation of the beta-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis. Mol Cell Endocrinol. 2018. doi: 10.1016/j.mce.2018.08.001. PubMed PMID: 30121202
Landon-Cardinal O, Friedman D, Guiguet M, Laforet P, Heming N, Salort-Campana E, Jouen F, Allenbach Y, Boyer O, Chatenoud L, Eymard B, Sharshar T, Benveniste O. Efficacy of Rituximab in Refractory Generalized anti-AChR Myasthenia Gravis. J Neuromuscul Dis. 2018;5(2):241-9. doi: 10.3233/JND-180300. PubMed PMID: 29865089
Lezmi G, Leite-de-Moraes M. Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients. Front Immunol. 2018;9:1766. doi: 10.3389/fimmu.2018.01766. PubMed PMID: 30105031; PubMed Central PMCID: PMCPMC6077286
Lezmi G, Abou Taam R, Dietrich C, Chatenoud L, de Blic J, Leite-de-Moraes M. Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma. Clin Immunol. 2018;188:7-11. doi: 10.1016/j.clim.2017.11.009. PubMed PMID: 29196148.
Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U. Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes. JCI Insight. 2018;3(6). doi: 10.1172/jci.insight.96244. PubMed PMID: 29563329; PubMed Central PMCID: PMCPMC5926942
Rignault-Bricard R, Machavoine F, Mecheri S, Hermine O, Schneider E, Dy M*, Leite-de-Moraes M*. IL-3-producing basophils are required to exacerbate airway hyper-responsiveness in a murine inflammatory model. Allergy. 2018. doi: 10.1111/all.13480. PubMed PMID: 29777594
* corresponding authors
You S, Chatenoud L. Revisiting the phenotypic and genetic profiling of anergic T cells mediating long-term transplant tolerance. Curr Opin Organ Transplant. 2018;23(1):83-9. doi: 10.1097/MOT.0000000000000494. PubMed PMID: 29194071