Institut Necker Enfants Malades is committed to advancing health through innovative biomedical research. By employing rigorous scientific methods, our researchers delve into the underlying mechanisms of diseases, aiming to shape innovative therapeutic approaches.

The research teams at INEM are organized into two departments. These departments foster the exchange of ideas and expertise among research teams within and across departments, as well as in collaboration with national and international experts in their respective fields of interest.

Department of Cell Biology: Growth and Signaling

Leaders: Mario Pende & Marco Pontoglio

The Cell Biology Department is dedicated to investigating growth and metabolic adaptations in a range of human pathophysiological conditions. This includes chronic kidney disease, cancer, mitochondrial diseases, neurocognitive impairment, cystic fibrosis and diabetes. Working in close collaboration with the hospital, our group leaders leverage their internationally recognized expertise to delve into fundamental biological processes. These processes encompass the cell cycle, autophagy, mitochondrial dynamics, hormone-growth factor-nutrient signal transduction, transcriptional networks, and epigenetics.

• Immunity and metabolism of Diabetes - IMMEDIABNicolas VENTECLEF
• Mechanisms and therapeutics of chronic kidney diseaseFabiola TERZI
• Epigenetics and developmentMarco PONTOGLIO
• Protein misfolding in respiratory epithelial diseasesIsabelle SERMET-GAUDELUS
• Cell growth control by nutrientsMario PENDE
• Mechanisms of nutrient sensingGanna PANASYUK
• Integrative neurobiologyFranck OURY
• Cellular & membrane dynamics in stress response - MEMBRAMICSEtienne MOREL
• Prolactin and Growth Hormone pathophysiologyVincent GOFFIN
• Translational and personalized medicineGuillaume CANAUD

Department of Immunology, Infectiology, and Hematology

Leaders: Simon Fillatreau & Peter van Endert

The Immunology, Infectiology and hematology - I2H department is a dynamic hub that unites experts in immunology, microbiology, and hematology. Our scientists have a strong track record in various crucial areas, including normal and pathological B and T cell differentiation, autoimmunity, immune regulation and therapy, antigen presentation, pathogenesis of systemic infections, and microbiota research. This department is committed to pushing the boundaries of research, as evidenced by the recruitment of young groups specializing in systems biology applied to host-pathogen interactions and leukocyte mobility. Furthermore, we actively engage in transdisciplinary collaborations with scientists from the Cell Biology Department, exploring areas such as metabolism, autophagy, and the regulation of cell growth.

• Immune pathways in autoimmune disordersPeter VAN ENDERT
• Leukomotion labPablo VARGAS
• Host-Microbiota interactionPamela SCHNUPF
• Pathogenesis of systemic infectionsXavier NASSIF & Alain CHARBIT
• Immune response and danger signalsBénédicte MANOURY
• Immunity in health and diseaseSimon FILLATREAU
• Immunoregulation and immunopathologyLucienne CHATENOUD & Maria LEITE DE MORAES
• Normal and pathological lymphoid differentiationVahid ASNAFI & Elizabeth MACINTYRE
• Genome plasticity and infectionsLaurence ARBIBE
• Auto-immune and B cells immune responses, AI2BMatthieu MAHEVAS