Institut Necker Enfants Malades

Tuesday 5 of December, 2023
Just Published: The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells by Aurore Claude-Taupin
In their recently published paper in Nature Communications, Aurore Claude-Taupin et al. explore the critical role of shear stress, a known regulator of renal function, and its dysregulation in various kidney diseases.
Building on prior research highlighting the significance of primary cilium-dependent autophagy in kidney epithelial cells' response to fluid flow, a new dimension has emerged.
Key Insights

Nuclear YAP/TAZ's involvement in negatively regulating [...]

Tuesday 28 of November, 2023
Just Published: Canonical and Non-Canonical Roles of SNX1 and SNX2 in Endosomal Membrane Dynamics by Juliane Da Graça
In their recent review, published in Contact CTC, Juliane Da Graça, from Morel Lab, deep-dives into the fascinating world of endosomal membrane dynamics, uncovering the multifaceted functions of Sorting Nexins (SNXs), particularly focusing on SNX1 and SNX2.
Navigating the Endosomal Landscape: SNX1 and SNX2 boast a membrane-curvature domain and a phosphoinositide-binding domain, anchoring them to the PI3P-positive surface of endosomes. This positioning facilitates interactions [...]

Monday 6 of November, 2023
Pr Elizabeth Macintyre Receives the Prestigious Fondation Guillaumat-Piel 2023 Award from La Fondation pour la Recherche Médicale
We are delighted to announce that Elizabeth Macintyre one of our distinguished researchers and co-leader of the Normal and pathological lymphoid differentiation Team, has been honored with the Fondation Guillaumat-Piel 2023 Award from La Fondation pour la Recherche Médicale. This recognition underscores the exceptional contributions of our faculty members and the cutting-edge research conducted within our institution.
Professor Macintyre was recognized for her groundbreaking work in [...]

Saturday 14 of October, 2023
Pr Guillaume Canaud's Pioneering Work: Illuminating Hope for CLOVES Syndrome Patients - A feature in La Croix L'Hebdo Magazine
Marine Lamoureux from La Croix L'hebdo followed Pr Guillaume Canaud and his teams at Hôpital Necker Enfants Malades for an incredible six-month journey - the treatment of children with CLOVES Syndrome.
CLOVES Syndrome is a very rare congenital disorder characterized by a combination of vascular, skin, spinal, and bone or joint abnormalities. Pr Canaud discovered a treatment, thus a turning point in the lives of these patients and their families.
If you’re interested in [...]

Tuesday 10 of October, 2023
Aurore Claude-Taupin: winner of the Fondation LOreal-UNESCO For Women In Science French Young Talents Award
Aurore Claude-Taupin, Senior Postdoctoral Researcher in Etienne Morel's lab has been honored with the esteemed Fondation L'Oréal - UNESCO For Women In Science French Young Talents.
Aurore's journey towards a career in biological research began during her BTS Biotechnology studies. Her interest in this field grew as she conducted her thesis on the role of autophagy in breast cancer. Later, she moved to the United States with her husband and 5-month old daughter for a [...]

Tuesday 12 of September, 2023
Just published in Immunity: SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals

The team of Matthieu Mahévas and Pascal Chappert have been following up on their recent work on B cell responses in the context of SARS-CoV-2 infection and mRNA vaccination. Studying memory B cells and plasma cells post SARS-CoV-2 Omicron BA.1 breakthrough infection in individuals previously vaccinated with three doses of the COVID-19 mRNA vaccine, they show clear signs of antigen imprinting from the Hu-1 Spike encoded in the vaccine. However, the diversity of the [...]

Thursday 31 of August, 2023
Group leader positions at Institut Necker Enfants Malades, Université Paris Cité, Paris-France
The Institut Necker Enfants Malades (INEM, https://www.institut-necker-enfants-malades.fr/) invites applications for two group leader positions. Excellent future prospects and an upwards-scientific track record will be the principal selection criteria. We promote equal opportunities, strongly encouraging applications from female candidates and welcome applications from early career scientists as well as established PIs who wish to join INEM.
Candidates should have an innovative research [...]

Thursday 24 of August, 2023
Just published in Cell Reports: Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
Mitochondrial dysfunction is a critical process involved in plethora of pathologies. Morgan Gallazzini’s group in the team of Fabiola Terzi identified Lipocalin-2 as an inducer of mitochondrial dysfunction. By combining in cells and in vivo renal disease models the team demonstrated that Lipocalin-2 regulates mTOR activity and thus induces mitochondrial fragmentation and loss of function.
This work has been published in Cell Reports and is available to [...]

Support(s)

HRH Princess Caroline of Hanover, who through the Princess Grace Foundation, already supports medical research and anything that helps to relieve the sick children in France and around the world, has agreed to commit to our side so that our Center of Molecular medicine continues to meet the current challenges and fight diseases, and in particular the ones affecting children.

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