Just published in Immunity: Over the last 15 years, Pascal Chappert, Marie-Alix Espinasse and François Huetz in the team of Jean-Claude Weill and Claude-Agnès Reynaud investigated the molecular and cellular mechanisms behind the exceptional longevity of smallpox/vaccinia -specific memory B cells. Secrets to a long life: early affinity-based selection, long-lasting elongated telomeres, dedicated splenic niche and keeping metabolic activity up a NOTCH, see more here : https://www.cell.com/immunity/fulltext/S1074-7613(22)00413-7