Institut Necker Enfants Malades (INEM) is a leading biomedical research center with state-of-the-art core facilities on the Hôpital Necker-Enfants Malades campus. Known for its scientific excellence and pioneering medical contributions in transplantation, biotherapy, and gene therapy, INEM provides a dynamic environment for both basic research and translational innovation.

The host laboratory

The Protein misfolding in respiratory epithelial diseases lab, led by Prof. Isabelle Sermet-Gaudelus, focuses on advancing cystic fibrosis treatment. At the heart of the lab’s research is the exploration of misfolded protein biogenesis and correction, with a primary focus on the CFTR protein as the model system. The team is committed to understanding and addressing the complex challenges associated with Cystic Fibrosis to improve the lives of those affected.

About the project

Our group is seeking a post-doctoral fellow interested by airway inflammation. Our research aims to understand the inflammation pathways remodeled by highly efficient CFTR modulation including the protease anti-protease balance, oxidative stress and interaction with innate immune cells. This will be based on a multi-omic approach of patient primary airway culture under different experimental conditions, microfluidic experiments and study of sputum samples collected longitudinally in a pediatric cohort. We are more specifically interested in the interplay between inflammation and repair.

Your profile

We are looking for a motivated candidate with a PhD or MD/PhD, skilled in molecular biology and mammalian cell culture. While prior experience in inflammation research is a plus, it is not essential. Strong laboratory, analytical, and communication skills are key.

Contract & Application details

This is a 48-month position with a competitive salary based on experience. The position is available immediately, with a flexible start date.

To apply, please send your cover letter (detailing research interests and career goals), CV, and references to @email and @email.

Applications will be reviewed on a rolling basis until the position is filled.