Institut Necker Enfants Malades (INEM) is a biomedical research center located on the Necker campus. It benefits from numerous state-of-the-art core facilities. The Campus has a long-standing reputation for scientific excellence and key pioneering medical contributions (transplantation, biotherapy, gene therapy). It provides a vibrant environment for basic research and translational innovation.

The host laboratory

The MEBRAMICS lab is devoted to understand how mammalian cells mobilize organelles, endomembrane-based signaling platforms, and the autophagic machinery to adapt to various stress scenarios and external stimuli. These include nutrient fluctuations, mechanical forces, infections or exposure to solar UV.

The lab is seeking a highly motivated postdoctoral researcher to study the impact of shear stress on plasma membrane homeostasis in kidney epithelial cells.

About the project

Our lab is interested in the mechanisms by which cells integrate fluid shear stress intensity. We recently described that autophagy is dysregulated by increased shear stress intensity in kidney epithelial cells, mimicking the urinary flow in chronic kidney disease (Claude-Taupin et al., Nature Communications 2023). The project aims to better comprehend the molecular mechanisms involved in shear stress-dependent dysfunction of kidney proximal cells, focusing on the impact of shear stress on plasma membrane homeostasis.

Your profile

Highly motivated candidates with a PhD in molecular and cellular biology obtained during the past four years and with
experience in membrane trafficking, secretion and/or zebrafish model are encouraged to apply. The candidate must have
good communication skills in English.

The two-year position is available starting early 2025.

How to apply

Please send a concise cover letter with a statement of research interest and summary of previous research activity, a detailed
curriculum vitae, and two reference letters to Aurore Claude-Taupin: @email.

Key-words: shear stress, membrane remodeling, ATG-dependent processes, plasma membrane, kidney.